Egy msik tnyez, a nem fejlesztsi egy hormon ciklus, amely ll egy kis trt Hormone hormon, amely krl naplemente cskkenti a vizelet kivlasztst a vese az jszaka, hogy megakadlyozzk a szerzs teljes hlyag trtnjen. Ez a fejlds nem jelen a szletskor, s gyerekek ltalban fejlesztse ebben a ciklusban Mikor rik el a kt ves korban. Nhny gyermek a fejlds ksn trtnik. Bizonyos esetekben ez a hormon ciklus soha nem alakul ki, az sszes vezet gyakori gybavizels.
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